劉靜 薛梅 朱玲 丁麗 閻洪敏 王志東 韓冬梅 郭子寬 王恒湘

摘要 目的：觀察臍帶間充質干細胞（UC-MSCs）鞘內注射治療脊髓小腦性共濟失調（SCA）及多系統萎縮小腦型（MSA-C）的臨床效果。方法：對2009年10月至2010年9月14例SCA及10例MSA-C患者，給予UC-MSCs鞘內注射治療，1x106/kg.次， 1 次/周，4次為1個療程，其中3例SCA患者接受兩療程，余均接受1 個療程。采用世界神經病聯合會國際合作共濟失調評分量表(ICARS)及日常生活量表(ADL)對患者治療前后神經功能進行評定，分值越高表示神經功能缺損越嚴重。治療后對患者進行隨訪。結果： 27例次治療結束1個月與治療前兩組間比較 ICARS及ADL明顯降低(P < 0.01)，有顯著差異。有效患者多表現為行走、站立不穩、運動遲緩、上肢精細動作障礙、書寫困難、構音障礙等臨床癥狀得到改善。僅1例SCA患者治療無效。治療后常見的不良反應有頭暈（4例），腰痛（2例），頭痛（1例），均在1-3天內消失。41.61%（10/24例）的患者隨訪半年以上疾病仍在穩定狀態，而58.33%(14/24例)的患者已在治療后1-14個月（平均3個月）疾病進展。結論：UC-MSC鞘內注射治療是安全的，可在一定時間內一定程度上改善SCA及MSA-C患者的臨床癥狀，提高患者生活質量。

關鍵詞：臍帶間充質干細胞；脊髓小腦性共濟失調；多系統萎縮

Clinical analysis of umbilical cord mesenchymal stem cells treating spinocerebellar ataxia and multiple system atrophy-cerebellar type

LIU Jing1，XUE Mei1， ZHU Ling1, DING Li1, YAN Hongmin1, WANG Zhidong1,HAN Dongmei1, GUO Zikuan2, WANG Hengxiang1

1 100142 Department of Hematology, General Hospital of the Air Force, Beijing

2 100850 Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing

Abstract OBJECTIVE: To observe the clinical effect of umbilical cord mesenchymal stem cells (UC-MSCs) in treating spinocerebellar ataxia (SCA) and multiple system atrophy-cerebellar type（MSA-C） by intrathecal injection. METHODS: From October 2009 to September 2010, 14 cases withSCA and 10 cases MSA-C were given UC-MSCs by intrathecal injection, 1x106/kg.次， once a week, 4 times as a course.Besides 3 cases received 2 couses ,others received 1 couses. International Cooperative Ataxia Rating Scale (ICARS) and Activity of Daily Living Scale (ADL) were used to evaluate SCA and MSA-C patients’ neural function and ability of daily living,the greater scores, the severe damage. RESULTS: Compared with before treatment , patient’s ICARS and ADL was significant decreased at 1 month after treatment (P < 0.01).Only one patient has no response.In most effective patients,these clinical symptoms, such as unstable walking and standing , slow movement, upper limb fine motor disorder，writing difficulties ，dysarthria were improved. After treatment, common adverse effects are dizziness (4 patients), low back pain (2 cases), headache (1 case), all disappeared within 1-3 days. CONCLUSION: UC-MSCs implantation is safe,and can ameliorate clinical symptoms, as well as improve life quality of SCA and MSA-C patients to some extent.

Key Word umbilical cord mesenchymal stem cells， spinocerebellar ataxia ，multiple system atrophy

  Tag: 臍帶血| 臍帶| 臍帶幹細胞| 脂肪幹細胞| 胎盤幹細胞| 羊胎水| 抗衰老|